Paul A. Northcott, PhD, is an Assistant Member in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. During his PhD and postdoctoral training, Paul made several seminal contributions to the medulloblastoma literature, including the description of molecularly and clinically distinct consensus subgroups, comprehensive annotation of genomic and epigenomic landscapes, and the discovery of ‘enhancer hijacking’ as a novel mechanism of oncogene activation in brain tumors. Now as an independent Principal Investigator, Paul’s lab is focused on solving the molecular and cellular origins of medulloblastoma subgroups and their associated subtypes. Using a variety of highly integrative genomic approaches, the Northcott Lab aims to elucidate the molecular mechanisms responsible for medulloblastoma initiation, maintenance, progression, relapse, and metastasis. Novel candidate genes and pathways identified through these efforts are being functionally characterized in vitro and in vivo to improve understanding of the biological basis of medulloblastoma pathogenesis and generate genetically accurate preclinical models that will be essential for improving outcomes for patients and their families.