Wiliam Foulkes is a clinician-scientist with a long-standing interest in the causes and consequences of inherited susceptibility to cancer. His lab focuses on translational research, in that his work aim to uncover the reasons why some individuals within cancer-prone families have developed cancer. In addition, he has worked to characterize the clinico-pathological effect on these mutations, and to explore the underlying molecular mechanisms. Over the past 20 years, he has worked extensively on susceptibility to breast, colorectal and ovarian cancer. More recently, he has turned our attention to rare pediatric cancer susceptibility syndromes, such as that caused by germ-line mutations in DICER1 and to date, has published 50 papers on this topic.