Claudia Kleinman

Canada

Claudia Kleinman

Canada

Biography

Claudia Kleinman is an Assistant Professor in the Human Genetics Department and full-time investigator at the Lady Davis Research Institute, McGill University. She completed her PhD in Bioinformatics at the Université de Montréal in 2010, followed by a postdoctoral work at the McGill University and Genome Quebec Innovation Centre. Her research exploits genome-wide technologies and data science to understand mechanisms of gene expression. She has an interdisciplinary training that combines molecular biology, computer science, statistics and evolutionary biology, which she applies to the study of pathological transcriptional and RNA processing events, focusing particularly on pediatric brain tumors. She has developed and implemented methods for RNA editing and other chemical modifications, alternative splicing, non-coding RNA regulation, and integration with epigenomic data. Recently, her lab has focused on single-cell transcriptomic technologies to resolve cell-to-cell variation. They have used these tools to identify rare cells driving cancer progression and developed novel biophotonic methods for cell selection. They are now applying them to study key aspects of cancer biology.